Özet:

Introduction and Target: In early stages of acute coronary syndrome (ACS) it has been found that the circulated blood expression of miR-1 miR-133a and miR-133b has increased. However, the possible differences in the expression characteristics of these miRNAs in ST-up myocardial infarction (STEMI) and non-ST-up myocardial infarction (NSTEMI) incidents are unknown. The aim of our study is to explore the different expressive characteristics of the circule miR-1, miR-133a and miR-133b in STEMI and NSTEMI. Methods and Requirements: Peripheral blood samples were taken from 54 ACS phenomena (27 STEMI, 27 NSTEMI) and 20 healthy volunteers. By using the qRT-PCR method, the expression levels in the peripheral blood of miR-1, miR-133a and miR-133b were measured. The relationship between the results of myRNA expression analysis and STEMI and NSTEMI was evaluated using the network-based software "RT2 Profiler PCR Array Data Analysis". ACS cases found that miR-1, miR-133a and miR-133b were higher than the expression levels of the control group (P<0.05). However, in STEMI and NSTEMI cases, it was observed that the myrna expression profile varied depending on time. In STEMI cases, the levels of myRNA expression showed a positive correlation with CK-MB, and in NSTEMI cases, a negative correlation. Our study shows that expression changes in miR-1, miR-133a and miR-133b can predict the severity and progress of coronary heart disease in ACS events, but our findings need to be supported by functional studies and in wider groups of patients.

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