Objective: The etiology of deep vein thrombosis disease is multifactorial, and currently it is seen as a public health problem. Simple, cheap and useful tests that can be used for diagnosis, treatment, and follow-up is increasingly needed day by day because of increasing number of patients. For this purpose, the changes of platelet indices in routine hemogram tests during DVT follow-up were examined retrospectively. Method: This study is a retrospective analysis of patients who diagnosed with deep venous thrombosis in Sivas Cumhuriyet University School of Medicine between 01.01.2017-31.12.2018 years. The investigation started after the decision of Sivas Cumhuriyet University Local Ethics Committee No. 2019-02/67. The acute, subacute and chronic phase parameters of patients with deep venous thrombosis were evaluated. The study included 72 patients who developed DVT. Platelet indexes and other hemogram parameters were analyzed statistically according to the phases of deep vein thrombosis. Results: 55.6% of the patients were female, and 44.4% were male. DVT was found most commonly in the left femoral region (48.6%). PDW and MPV tended to increase rapidly in the acute phase of deep vein thrombosis and managed to fall in the subacute and chronic phases. However, there was no statistically significant change in platelet count and platelet crit. Conclusions: PDW and MPV appear to be useful markers in the follow-up of all stages of deep vein thrombosis. It is evident that with the developing technology, more sensitive and specific parameters of platelet indices will be obtained.