Abstract:

Objective: Renal cell carcinoma (RCC) of the kidney constitutes approximately 2-4% of adult tumors. Approximately 80% of renal cell cancer cases are defined as clear cell renal cell carcinoma. The aim of this study was to review the renal cell carcinoma cases in our archive to provide additional information to the literature. Material and Methods: 52 cases of renal tumors diagnosed in our pathology laboratory between 2010-2019 were reviewed retrospectively for histopathological diagnosis, tumor size and nuclear grade. Results: 34 (65%) of the cases were male and 18 (34%) were female. The age of the cases ranged between 33 and 85 years, with an average age of 58 years. Of the fifty-two kidney tumors, 34 (65%) were clear cell renal cell carcinoma, 5 (10%) were chromophobe renal cell carcinoma, 5 (10%) were papillary renal cell carcinoma, 2 (3%) were oncocytoma and 6 (12%). It is unclassified renal cell carcinoma. Fifteen (34.1%) of the tumors were nuclear grade (NG) 1, 13 (29.5%) were NG 2, 12 (27.3%) were NG 3 and 4 (9%) were NG 4. The histological subtype with the largest (10.5 cm) tumor diameter was clear cell renal cell carcinoma, while papillary renal cell carcinoma was with the smallest (1 cm) tumor diameter. Conclusion: Tumor type, sarcomatoid / rhabdoid differentiation, tumor necrosis and grading in RCC are considered as potential prognostic parameters. Determination of papillary renal cell cancer subtypes (type 1 and 2) provides additional prognostic information and clear cell tubulopapillary renal cell cancer has been associated with a better prognosis. Tumors showing sarcomatoid or rhabdoid differentiation should be indicated regardless of the percentage of these histopathological features. It is that tumor necrosis has a prognostic significance by the evaluation based on macroscopic and microscopic examination. Nucleolar prominence defines grade 1 to 3 in clear cell and papillary renal cell carcinomas. Extreme nuclear pleomorphism or sarcomatoid and/or rhabdoid differentiation showing tumors are graduated as grade 4. In addition to the grading, pT stage is to maintain its prognostic significance.

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